Fibroblast-Like Synovial Cell Subsets in Rheumatoid Arthritis

Fibroblasts like synoviocytes (FLS) play several significant roles in rheumatoid arthritis (RA) pathophysiology. This chapter will describe known of FLS disease initiation, joint inflammation, persistence and destruction. It the newly characterized subsets based on single cell RNA sequencing studies, their association to specific aspects disease. Finally, we discuss future targeting treatment RA. The synovial lining layer are identified by surface complement decay-accelerating factor (CD55) along with lubricin metallopeptidase expression. Pathological activation this subset result bone cartilage damage mice. sublining often THY1 expression, but recent studies have highlighted a heterogeneity where distinct additional markers. Sublining expressing human leukocyte antigen-DRA (HLA-DRA) produce C-X-C motif chemokine 12 (CXCL12) receptor activator nuclear factor-κB ligand (RANKL) seems constitute pro-inflammatory that is associated inflammation tertiary lymphoid structures. Another CD34 expression may discriminate common progenitor fibroblast subset. Taken together, isolating characterizing gene report both associations unknown importance markers impose protective or destructive features. supports evidence as active players RA pathology capable cellular recruitment, local crosstalk promotion These discoveries serve an atlas for potential development targeted treatment.